Carcinoma in situ (CIS)

A lesion comprised of “cancer cells” but with those cells limited to the lining [intlink id=”356″ type=”post”]mucosa[/intlink] and without evidence of extension to adjacent structures. In other words, there is no sign of invasion beyond the mucosa. CIS is typically a localized and highly curable precursor to invasive [intlink id=”77″ type=”post”]cancer[/intlink]. CIS is sometimes called intraepithelial carcinoma. In laryngology, this entity is found primarily on the vocal folds themselves, where a tiny, early lesion can change the quality of the voice. In other locations, CIS would ordinarily be “silent.”

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